An RCSU of a service or unit of reference specializes in a technique, technology or procedure for the treatment of certain pathologies or groups of pathologies and which fulfil one or several of the criteria stipulated in Royal Decree 1302/2006, regardless of whether or not this service or unit treats other pathologies for which it does not have reference status An RCSU has to:

• Provide coverage for the entire national territory and treat patients under equal conditions regardless of their place of residence.
• Provide treatment in a multidisciplinary team: healthcare treatment, support for diagnostic confirmation, definition of therapeutic and monitoring strategies and acting as a consultant for the clinical units that regularly treat the patients in question.
• Guarantee the continuity of treatment between the stages of the patient's life (child-adult) and between healthcare levels.
• Evaluate the results.
• Training other professionals.

The following Reference Centres, Services and Units (RCSU) are currently recognized at the Hospital:

• HPT in paediatric haemato-oncological patients
• Functional Unit for Neuromuscular Disorders (UFMNM)
• Functional unit for the treatment of malignant mesenchymal and soft tissue tumours
• Exstrophy-epispadias complex (vesical exstrophy, epispadias and cloacal exstrophy) in adults and children.
• Complex glomerular diseases (adults and children).
• Hereditary eritropathology (adults and children).
• Hypothalamic-pituitary complex pathology.